Can antidepressants cause vaginal dryness permanently?
Antidepressants, especially SSRIs and SNRIs, can cause vaginal dryness as a side effect, but this is usually reversible when medication is stopped or changed. Persistent dryness should be discussed with a healthcare provider.
Detailed Medical Explanation
Selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), and some tricyclic antidepressants can decrease vaginal lubrication by altering neurotransmitters involved in sexual function. In most cases, vaginal dryness resolves if the dose is reduced or a different medication is prescribed. Rarely, dryness may persist due to additional factors like menopause or underlying health conditions. NHS: Antidepressants Side Effects.
Clinical Context
We review medication side effects and collaborate with mental health teams to find suitable alternatives if dryness is bothersome. Do not stop antidepressants suddenly—speak to your GP for safe management.
Evidence-Based Approaches
Current guidelines recommend addressing side effects through medication adjustment or symptom management. Persistent dryness may require gynaecological evaluation. BNF: Antidepressants and Sexual Side Effects.