What causes some patients to be non-responders to laser therapy?
Some women do not respond to vaginal laser therapy due to factors such as advanced atrophy, hormonal deficiency, medical comorbidities, incorrect diagnosis, or suboptimal treatment protocols.
Detailed Medical Explanation
Non-response can occur if the underlying issue is not suitable for laser (e.g., severe oestrogen deficiency, pelvic floor dysfunction, chronic infection, or neurologic causes of symptoms). Poor response may also result from insufficient treatment sessions, inappropriate energy settings, or failure to optimise vaginal health prior to therapy. Other contributing factors include diabetes, smoking, and medications affecting healing. Thorough clinical assessment is essential before deciding on further interventions. For more, see NICE guidance and RCOG GSM.
Clinical Context
A comprehensive review with a specialist can identify modifiable factors and alternative therapies for non-responders.
Evidence-Based Approaches
Personalised treatment and optimisation of underlying health improves response rates. See NICE guidance.