What medications can cause dyspareunia as side effect?
Some medications, including certain antidepressants, antihistamines, chemotherapy agents, and hormonal contraceptives, can cause dyspareunia by reducing vaginal lubrication or affecting hormones.
Detailed Medical Explanation
Medications that lower oestrogen (such as GnRH analogues for endometriosis, or some breast cancer therapies) frequently cause vaginal dryness and pain with sex. Other drugs—like certain antidepressants (SSRIs, SNRIs), antihistamines, antihypertensives, and oral contraceptives—may reduce lubrication or libido, leading to dyspareunia. Reviewing medications is an important part of assessment. BNF: Drug Side Effects.
Clinical Context
If you notice pain with sex after starting a new medication, discuss this with your GP or pharmacist. Adjusting medication or using vaginal moisturisers may help.
Evidence-Based Approaches
NHS and BNF guidelines recommend regular review of medication lists in women with new or persistent dyspareunia. Alternative medicines or supportive treatments may be considered. NHS Medicines.