What happens if UTI antibiotics don’t work?
If antibiotics do not improve UTI symptoms within 48 hours, the infection may be resistant or another condition may be present. Further testing and a change of antibiotic may be needed.
Detailed Medical Explanation
If symptoms persist after 48 hours, your UTI may be caused by antibiotic-resistant bacteria or another diagnosis may be needed. A urine sample will often be sent for culture and sensitivity testing to guide the next choice of antibiotic. Hospital admission may be required for severe infections. NHS: When UTI antibiotics fail.
Clinical Context
Clinics will reassess, order further urine tests, and may prescribe a different antibiotic if your symptoms do not improve as expected.
Evidence-Based Approaches
NHS and NICE guidelines recommend follow-up and urine culture for persistent or recurrent UTI symptoms.