What antidepressants cause reduced vaginal sensation?
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are the antidepressants most commonly linked to reduced vaginal sensation and sexual side effects.
Detailed Medical Explanation
SSRIs (such as fluoxetine, sertraline, and citalopram) and SNRIs (such as venlafaxine and duloxetine) are well known to cause sexual side effects, including reduced libido, difficulty achieving orgasm, and decreased vaginal sensitivity. The impact varies by individual and dose. Tricyclic antidepressants and other classes may also have effects but are less commonly reported. If symptoms persist, consult your healthcare provider for alternative treatment options. NHS: SSRI side effects.
Clinical Context
Sexual side effects are a common reason for stopping antidepressants. Open discussion with your prescriber can help find the best approach for your mental and sexual health.
Evidence-Based Approaches
NICE guidelines support medication review, dose adjustment, or switching antidepressants for those affected by sexual side effects (NICE CKS).