Does lichen sclerosus run in families genetically?
Lichen sclerosus sometimes runs in families, suggesting a genetic predisposition, but most cases occur without a clear family history. The main risk factors are likely to be genetic and immune-related.
Detailed Medical Explanation
Research shows an increased prevalence of autoimmune diseases and lichen sclerosus among first-degree relatives, supporting a genetic link. Specific genes, especially related to immune regulation (HLA genes), may increase susceptibility. However, environmental and hormonal factors also play a role. For further details, see NHS and BAD.
Clinical Context
If you or a close relative has lichen sclerosus, awareness of symptoms and early intervention are key. Our clinic provides family-based education and support: Vulval Skin Conditions Clinic.
Evidence-Based Approaches
While genetics play a role, not all family members are affected. See British Association of Dermatologists for more information.