Can antihistamines cause chronic vaginal dryness?
Antihistamines can cause vaginal dryness as a side effect by reducing the body’s overall moisture production, but this is usually temporary and improves when the medication is stopped.
Detailed Medical Explanation
Antihistamines such as loratadine, cetirizine, and diphenhydramine are used to treat allergies by blocking histamine, but also reduce secretions from mucous membranes throughout the body. This can lead to dryness in the mouth, eyes, and vagina. Chronic use can prolong symptoms. If dryness persists, consult your GP for alternative medications or symptom management. NHS: Antihistamines Side Effects.
Clinical Context
We routinely review medication side effects for patients with chronic dryness. Alternatives or topical therapies may be offered if symptoms are bothersome.
Evidence-Based Approaches
Guidelines recommend medication review and minimising long-term use where possible. Lubricants and moisturisers are safe adjuncts for relief. RCOG: Medication Side Effects.