Can antidepressants help with hot flushes?
Yes, certain low-dose antidepressants—particularly SSRIs and SNRIs—are sometimes prescribed to help reduce the frequency and severity of menopausal hot flushes.
Detailed Medical Explanation
Certain antidepressants, including selective serotonin reuptake inhibitors (SSRIs) like citalopram and paroxetine, and serotonin-norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine, have been shown to provide moderate relief from vasomotor symptoms. They are usually considered when HRT is unsuitable or declined. The dose prescribed for hot flushes is typically lower than that used for depression. For more, visit the BNF menopause treatment summary.
Clinical Context
SSRIs and SNRIs are useful for women who cannot take hormones or prefer not to use HRT. They may also help with menopausal mood symptoms. Regular follow-up is recommended to monitor effectiveness and side effects.
Evidence-Based Approaches
Clinical trials confirm that antidepressants can reduce hot flushes by 50–60% in some women. NICE recommends considering non-hormonal options when HRT is contraindicated. See NICE menopause guidance for further advice.