Can tacrolimus ointment help with lichen sclerosus?
Tacrolimus ointment may be helpful for some people with lichen sclerosus, particularly when steroid creams are not effective or suitable. However, it is usually considered a second-line or alternative treatment.
Detailed Medical Explanation
Tacrolimus is a calcineurin inhibitor that reduces inflammation by suppressing the immune response in the skin. Studies show it can be beneficial in some women who cannot tolerate steroids or have refractory disease. However, it is less effective than clobetasol and should be used with caution due to potential local irritation and rare risk of malignancy with long-term use. More details at NICE BNF and British Association of Dermatologists.
Clinical Context
Tacrolimus may be considered for women who are unable to use steroids or who experience side effects. It should only be used under specialist supervision. Our clinic offers individualised care plans: Vulval Skin Conditions Clinic.
Evidence-Based Approaches
International guidelines state that calcineurin inhibitors are an option for recalcitrant or steroid-intolerant cases. Monitoring is advised due to safety concerns. See NICE BNF.